反应详情

A solution of 5-bromo-o-anisaldehyde (25 g, 116 mmol), 1,3-propandiol (9 mL, 125 mmol), p-toluenesulphonic acid (0.1 g) in toluene (150 mL) was heated and water was azeotropically removed using a Dean-Stark water-separator. After 18 hours, the solution was washed with 5% Na2CO3 (100 ml), dried (K2CO3) and the solvent was removed under reduced pressure. The acetal was purified by vacuumdistillation and isolated as clear oil:

1. customwater was azeotropically removed
2. washthe solution was washed with 5% Na2CO3 (100 ml)
3. dry with materialdried (K2CO3)
4. customthe solvent was removed under reduced pressure
5. distillationThe acetal was purified by vacuumdistillation
6. customisolated as clear oil