反应详情

温度

25 °C

A solution of 2-(4-methoxy-phenyl)-2-methyl-propionitrile (17.5 g, 0.10 mol) in TFA (80 mL) was cooled to 0° C. N-bromosuccinimide (17.8 g, 0.10 mol) was added in small portions keeping the temperature below 5° C. The orange solution was stirred for 2 h/25° C. and evaporated to dryness. Water (200 mL) was added and the mixture was stirred vigorously for 1 h. The crude product was filtered off and recrystallized from boiling MeOH. The pure product was isolated as white needles. Yield: 19.3 g (76%). GCMS: >99%

1. customthe temperature below 5° C
2. customevaporated to dryness
3. additionWater (200 mL) was added
4. stirringthe mixture was stirred vigorously for 1 h
5. filtrationThe crude product was filtered off
6. customrecrystallized
7. customThe pure product was isolated as white needles