Hydrochloric Acid → HCID 67465072, compound

Participants

Reaction Steps

A mixture of intermediate (3) (0.19 mol) in HCl (36%; 100 ml) was stirred and refluxed for 5 hours, then stirred overnight at room temperature. The precipitate was filtered off and triturated under 2-propanol, filtered off and dried, yielding 5 g of α-phenyl-4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]phenyl]-1-piperazineacetic acid monohydrochloride (intermediate 4).

Provenance & Evidence