Hydrochloric Acid → HCID 67465072, compound

HRID 1989856Notes

Reaction equation

HRID 1989856 reaction equation
[C:1]1([CH:7]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([NH:24][C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[C:33]4[CH:38]=[CH:37][C:36]([C:39]([F:42])([F:41])[F:40])=[CH:35][CH:34]=4)=[O:26])=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)[C:8]([O:10]C)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:43]>>[ClH:43].[C:1]1([CH:7]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:19]=[CH:20][C:21]([NH:24][C:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[C:33]4[CH:34]=[CH:35][C:36]([C:39]([F:42])([F:41])[F:40])=[CH:37][CH:38]=4)=[O:26])=[CH:22][CH:23]=3)[CH2:14][CH2:13]2)[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 10120773HCID 10120773, compound

Product 1

HCID 67465072HCID 67465072, compound

Procedure

A mixture of intermediate (3) (0.19 mol) in HCl (36%; 100 ml) was stirred and refluxed for 5 hours, then stirred overnight at room temperature. The precipitate was filtered off and triturated under 2-propanol, filtered off and dried, yielding 5 g of α-phenyl-4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]phenyl]-1-piperazineacetic acid monohydrochloride (intermediate 4).

Workup

  1. temperaturerefluxed for 5 hours
  2. stirringstirred overnight at room temperature
  3. filtrationThe precipitate was filtered off
  4. customtriturated under 2-propanol
  5. filtrationfiltered off
  6. customdried

Sources & evidence

ORD record
ord-7b5dadf709ea44dcb8d67252b1d72f50
Source dataset
uspto-grants-2010_01
Patent number
US07642378B2

Reaction notes

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