HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1989875Generated: November 1, 2026
Ammonium Hydroxide → 4-[1,2,3,6-Tetrahydro-1-(phenylmethyl)-4-pyridinyl]benzenamine
https://huagongshe.com/reaction/1989875
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 1-Benzyl-4-(p-bromophenyl)-4-piperidinol hydrochloride | HCID 17989468 | — |
| Product | 4-[1,2,3,6-Tetrahydro-1-(phenylmethyl)-4-pyridinyl]benzenamine | HCID 22499416 | — |
Reaction Steps
A mixture of 1-benzyl-4-(p-bromophenyl)-4-piperidinol hydrochloride (0.23 mol) and Cu2O (2 g) in NH4OH (500 ml) was stirred at 180° C. for 12 hours. The mixture was cooled, extracted with DCM and washed with water. The organic layer was dried, filtered off and evaporated, yielding 60 g of 4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]benzenamine (intermediate 47).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07642378B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-e8435a6da6864c6d8cfa026bdcdee4e2 |
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| Source note | uspto-grants-2010_01 |
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