反应详情

温度

180 °C

A mixture of 1-benzyl-4-(p-bromophenyl)-4-piperidinol hydrochloride (0.23 mol) and Cu2O (2 g) in NH4OH (500 ml) was stirred at 180° C. for 12 hours. The mixture was cooled, extracted with DCM and washed with water. The organic layer was dried, filtered off and evaporated, yielding 60 g of 4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]benzenamine (intermediate 47).

1. temperatureThe mixture was cooled
2. extractionextracted with DCM
3. washwashed with water
4. customThe organic layer was dried
5. filtrationfiltered off
6. customevaporated