Trifluoroacetic acid → HCID 68525984, compound

Participants

Reaction Steps

Combine 4-cyano-3-{4-[2-(2,2-dimethyl-propionylamino)-ethoxy]-phenyl}-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl ester (211 mg, 0.45 mmol) and CH2Cl2 (1 ml), add trifluoroacetic acid 99% (1 ml) and stir at room temperature for 2 days. Remove the solvents in vacuo to give 222 mg (quantitative yield) of title compound: Rf (hexane:ethyl acetate, 4:1)=0.1. Mass spectrum (EI+): m/z 363 (M++1 free base).

Provenance & Evidence