Trifluoroacetic acid → HCID 68525984, compound

HRID 1990080Notes

Reaction equation

HRID 1990080 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[S:7][C:8]([S:29][CH3:30])=[C:9]([C:27]#[N:28])[C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][NH:20]C(=O)C(C)(C)C)=[CH:13][CH:12]=1)=[O:5])[CH3:2].[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>C(Cl)Cl>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[CH2:1]([O:3][C:4]([C:6]1[S:7][C:8]([S:29][CH3:30])=[C:9]([C:27]#[N:28])[C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][NH2:20])=[CH:13][CH:12]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68525529HCID 68525529, compound

Product 1

HCID 68525984HCID 68525984, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Combine 4-cyano-3-{4-[2-(2,2-dimethyl-propionylamino)-ethoxy]-phenyl}-5-methylsulfanyl-thiophene-2-carboxylic acid ethyl ester (211 mg, 0.45 mmol) and CH2Cl2 (1 ml), add trifluoroacetic acid 99% (1 ml) and stir at room temperature for 2 days. Remove the solvents in vacuo to give 222 mg (quantitative yield) of title compound: Rf (hexane:ethyl acetate, 4:1)=0.1. Mass spectrum (EI+): m/z 363 (M++1 free base).

Workup

  1. customRemove the solvents in vacuo

Sources & evidence

ORD record
ord-a048fd8fdb7740f7b7df4f9e4c171e43
Source dataset
uspto-grants-2010_01
Patent number
US07642361B2

Reaction notes

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