Hydrochloric Acid → HCID 86612411, compound

Participants

Reaction Conditions

Reaction Steps

Add ethanol (50 ml) and 1M aqueous solution of NaOH to 3-(4-(bromophenyl)-4-cyano-5-ethyl-thiophene-2-carboxylic acid ethyl ester (5.0 g, 13.73 mmol) and stir at 60° C. for 1h. Cool down and acidify with 3M HCl until white solid precipitates. Filter and wash solid with water and hexanes successively. Dry overnight to give 4.34 g as a white solid. Mass spectrum ESI positive (m/z): 366 (M+1).

Provenance & Evidence