Hydrochloric Acid → HCID 86612411, compound

HRID 1990108Notes

Reaction equation

HRID 1990108 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[S:9][CH:10]([CH2:22][CH3:23])[C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Br:21])([C:13]#[N:14])[CH:12]=1)=[O:7])C.Cl>C(O)C>[Br:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:11]1([C:13]#[N:14])[CH:10]([CH2:22][CH3:23])[S:9][C:8]([C:6]([OH:7])=[O:5])=[CH:12]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86612412HCID 86612412, compound

Product 1

HCID 86612411HCID 86612411, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

Add ethanol (50 ml) and 1M aqueous solution of NaOH to 3-(4-(bromophenyl)-4-cyano-5-ethyl-thiophene-2-carboxylic acid ethyl ester (5.0 g, 13.73 mmol) and stir at 60° C. for 1h. Cool down and acidify with 3M HCl until white solid precipitates. Filter and wash solid with water and hexanes successively. Dry overnight to give 4.34 g as a white solid. Mass spectrum ESI positive (m/z): 366 (M+1).

Workup

  1. temperatureCool down
  2. customprecipitates
  3. filtrationFilter
  4. washwash solid with water and hexanes successively
  5. customDry overnight
  6. customto give 4.34 g as a white solid

Sources & evidence

ORD record
ord-1337fb0d6f164010a7d7597395fe33fb
Source dataset
uspto-grants-2010_01
Patent number
US07642361B2

Reaction notes

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