HCID 178502860, compound → HCID 178502859, compound

HRID 1990747Notes

Reaction equation

HRID 1990747 reaction equation
[N:1]([CH2:4][C:5]1[CH:15]=[CH:14][C:8]([C:9]([NH:11][O:12][CH3:13])=[NH:10])=[CH:7][CH:6]=1)=[N+]=[N-]>C(O)C.O=[Pt]=O>[NH2:1][CH2:4][C:5]1[CH:15]=[CH:14][C:8]([C:9]([NH:11][O:12][CH3:13])=[NH:10])=[CH:7][CH:6]=1

Participants

4

Reactant 1

HCID 178502860HCID 178502860, compound

Product 1

HCID 178502859HCID 178502859, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

To a solution of 4-azidomethyl-N-methoxy-benzamidine (11.3 g, 0.055 mol; see step (i) above) in 200 mL of ethanol was added 200 mg of PtO2. The mixture was hydrogenated with constant bubbling of hydrogen for 4 h and subsequently filtered through Celite® and evaporated. Yield: 7.34 g (74%).

Workup

  1. customwith constant bubbling of hydrogen for 4 h
  2. filtrationsubsequently filtered through Celite®
  3. customevaporated

Sources & evidence

ORD record
ord-15aba10ab47942468e3c60a329d2001c
Source dataset
uspto-grants-2010_01
Patent number
US07645751B2

Reaction notes

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