反应详情

15.02 g (0.10 mol) of 4′-methoxyacetophenone and a 45% toluene solution (25 ml) of ethyl glyoxalate were stirred overnight at 100° C. The reaction liquid was concentrated under reduced pressure, and the resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=2/1) to obtain 20.62 g (yield: 82%) of ethyl 2-hydroxy-4-(4-methoxyphenyl)-4-oxo-butyrate as a yellow oily substance.

1. customThe reaction liquid
2. concentrationwas concentrated under reduced pressure
3. customthe resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=2/1)