Chloroform → HCID 135599849, compound

HRID 1990777Notes

Reaction equation

HRID 1990777 reaction equation
ClCCl.B(Br)(Br)Br.C(Cl)(Cl)Cl.C[O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[C:25]([CH3:26])=[N:24][N:23]3[CH:27]=[N:28][N:29]=[C:22]3[CH:21]=2)=[CH:16][CH:15]=1>O>[CH3:26][C:25]1[C:20]([C:17]2[CH:18]=[CH:19][C:14]([OH:13])=[CH:15][CH:16]=2)=[CH:21][C:22]2[N:23]([CH:27]=[N:28][N:29]=2)[N:24]=1

Participants

6

Reactant 4

HCID 6212ChloroformHCID 6344DichloromethaneHCID 25134Boron tribromideHCID 23153676HCID 23153676, compound

Product 1

HCID 135599849HCID 135599849, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.5 ml (1.41 mol) of a dichloromethane solution of 1 M boron tribromide was added to a chloroform solution (4 ml) of 107 mg (0.47 mmol) of the obtained 7-(4-methoxyphenyl)-6-methyl-[1,2,4]triazolo[4,3-b]pyridazine, and stirred overnight at room temperature. Water was added to the reaction liquid, extracted with chloroform, and the organic layer was washed with saturated saline water. This was dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 68 mg of a crude product of 4-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-phenol.

Workup

  1. extractionextracted with chloroform
  2. washthe organic layer was washed with saturated saline water
  3. dry with materialThis was dried with anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c6e941d0f2494e07883b121d041b5c76
Source dataset
uspto-grants-2010_01
Patent number
US07645756B2

Reaction notes

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