Chloroform → HCID 135599849, compound

Participants

Reaction Steps

1.5 ml (1.41 mol) of a dichloromethane solution of 1 M boron tribromide was added to a chloroform solution (4 ml) of 107 mg (0.47 mmol) of the obtained 7-(4-methoxyphenyl)-6-methyl-[1,2,4]triazolo[4,3-b]pyridazine, and stirred overnight at room temperature. Water was added to the reaction liquid, extracted with chloroform, and the organic layer was washed with saturated saline water. This was dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 68 mg of a crude product of 4-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-7-yl)-phenol.

Provenance & Evidence