HCID 86607634, compound → 4-Chloro-3-(2-fluoroethoxy)benzaldehyde

HRID 1990895Notes

Reaction equation

HRID 1990895 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][C:3]=1[O:10][CH2:11][CH2:12][F:13]>ClCCl.O=[Mn]=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][C:3]=1[O:10][CH2:11][CH2:12][F:13]

Participants

4

Reactant 1

HCID 86607634HCID 86607634, compound

Product 1

HCID 587063554-Chloro-3-(2-fluoroethoxy)benzaldehyde

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of [4-chloro-3-(2-fluoro-ethoxy)-phenyl]-methanol (1.19 g, 5.82 mmol, 1.0 equiv) in dichloromethane (60 mL) was added activated MnO2 (10.1 g, 116.31 mmol, 20.0 equiv). The reaction mixture was stirred vigorously for 6 h at ambient temperature and then filtered through Hyflo Super Cel providing after evaporation of the solvent under reduced pressure 0.91 g (77%) of the title compound. MS (EI): 202.0 [M]+.

Workup

  1. filtrationfiltered through Hyflo Super Cel
  2. customproviding
  3. customafter evaporation of the solvent under reduced pressure 0.91 g (77%) of the title compound

Sources & evidence

ORD record
ord-2174aefe3e4e4618a45cffdb1c1cf252
Source dataset
uspto-grants-2010_01
Patent number
US07645753B2

Reaction notes

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