HCID 68695975, compound → HCID 68693592, compound

HRID 1990901Notes

Reaction equation

HRID 1990901 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]2[N:19]=[C:20]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[NH:21][C:22]=2[CH3:23])[CH2:13][CH2:12]1.[CH3:30]C1N=C(C2C=C(C)C=CC=2)NC=1C=O.CC1N=C(C2C=CC=CC=2)NC=1C=O>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]2[N:19]=[C:20]([C:24]3[CH:29]=[C:28]([CH3:30])[CH:27]=[CH:26][CH:25]=3)[NH:21][C:22]=2[CH3:23])[CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 68695975HCID 68695975, compoundHCID 178424658HCID 178424658, compoundHCID 178432491HCID 178432491, compound

Product 1

HCID 68693592HCID 68693592, compound

Procedure

The title compound was prepared according to the procedure described for the synthesis of example 325 (benzooxazol-2-yl-[1-(5-methyl-2-phenyl-1H-imidazol-4-ylmethyl)-piperidin-4-yl]-amine) using 5-methyl-2-m-tolyl-3H-imidazole-4-carbaldehyde ([CAS RN 68283-20-5] prepared as described in U.S. Pat. No. 4,107,307 (American Cyanamid Company)) instead of 5-methyl-2-phenyl-3H-imidazole-4-carbaldehyde. MS (ESI): 402.5 [M+H]+.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-be6c7252a0c14eddb4f2e5a408c90d49
Source dataset
uspto-grants-2010_01
Patent number
US07645753B2

Reaction notes

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