Hydrochloric Acid → HCID 178422240, compound

HRID 1990916Notes

Reaction equation

HRID 1990916 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([OH:14])[C:3]=1[CH2:15][C:16]1([CH3:21])OCCO1.[ClH:22]>>[ClH:22].[CH3:21][C:16]1[NH:1][C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[N:5]=[C:4]([OH:14])[C:3]=2[CH:15]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178422219HCID 178422219, compound

Product 1

HCID 178422240HCID 178422240, compoundYield 78%

Procedure

A solution of acetal 3 (700 mg, 2.44 mmol) in 1 N HCl (40 mL) was stirred for 2 h at RT. The resulting slurry was filtered yielding the HCl salt 4 as a tan solid (498 mg, 78.0%):

Workup

  1. filtrationThe resulting slurry was filtered

Sources & evidence

ORD record
ord-df398e58082447a1af9ec8279c25ad02
Source dataset
uspto-grants-2010_01
Patent number
US07645754B2

Reaction notes

Loading…