4-Aminotetrahydropyran → HCID 25015968, compound

HRID 1991010Notes

Reaction equation

HRID 1991010 reaction equation
[CH3:1][N:2]1[C:7]2[N:8]=[C:9](SC)[N:10]=[CH:11][C:6]=2[CH:5]=[C:4]([C:14]2[CH:19]=[C:18]([C:20]3[O:24][N:23]=[C:22]([CH3:25])[CH:21]=3)[CH:17]=[CH:16][C:15]=2[CH3:26])[C:3]1=[O:27].OOS([O-])=O.[K+].[NH2:34][CH:35]1[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1>>[CH3:1][N:2]1[C:7]2[N:8]=[C:9]([NH:34][CH:35]3[CH2:40][CH2:39][O:38][CH2:37][CH2:36]3)[N:10]=[CH:11][C:6]=2[CH:5]=[C:4]([C:14]2[CH:19]=[C:18]([C:20]3[O:24][N:23]=[C:22]([CH3:25])[CH:21]=3)[CH:17]=[CH:16][C:15]=2[CH3:26])[C:3]1=[O:27]

Participants

4

Reactant 3

HCID 4192234-AminotetrahydropyranHCID 23707502Potassium hydroxy sulfiteHCID 59128641HCID 59128641, compound

Product 1

HCID 25015968HCID 25015968, compound

Procedure

8-Methyl-6-[2-methyl-5-(3-methyl-isoxazol-5-yl)-phenyl]-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one was treated with OXONE™ following the procedure of step 3 of Example 1, and the resulting sulfonyl compound was treated with 4-amino-tetrahydropyran using the procedure of step 4 of Example 1, to give 8-Methyl-6-[2-methyl-5-(3-methyl-isoxazol-5-yl)-phenyl]-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one: MS (M+H)=432.

Sources & evidence

ORD record
ord-8e0e9a0e60254be39efee6dd6bacd403
Source dataset
uspto-grants-2010_01
Patent number
US07645764B2

Reaction notes

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