4-Aminotetrahydropyran → HCID 178424062, compound

HRID 1991012Notes

Reaction equation

HRID 1991012 reaction equation
[CH3:1][N:2]1[C:7]2[N:8]=[C:9](SC)[N:10]=[CH:11][C:6]=2[CH:5]=[C:4]([C:14]2[CH:19]=[C:18]([C:20]3[NH:24][CH:23]=[N:22][N:21]=3)[CH:17]=[CH:16][C:15]=2[CH3:25])[C:3]1=[O:26].OOS([O-])=O.[K+].[NH2:33][CH:34]1[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1>>[CH3:1][N:2]1[C:7]2[N:8]=[C:9]([NH:33][CH:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)[N:10]=[CH:11][C:6]=2[CH:5]=[C:4]([C:14]2[CH:19]=[C:18]([C:20]3[NH:24][CH:23]=[N:22][N:21]=3)[CH:17]=[CH:16][C:15]=2[CH3:25])[C:3]1=[O:26]

Participants

4

Reactant 3

HCID 4192234-AminotetrahydropyranHCID 23707502Potassium hydroxy sulfiteHCID 178503377HCID 178503377, compound

Product 1

HCID 178424062HCID 178424062, compound

Procedure

8-Methyl-2-methylsulfanyl-6-[2-methyl-5-(4H-[1,2,4]triazol-3-yl)-phenyl]-8H-pyrido[2,3-d]pyrimidin-7-one was treated with OXONE™ following the procedure of step 3 of Example 1, and the resulting sulfonyl compound was treated with 4-amino-tetrahydropyran using the procedure of step 4 of Example 1, to give 8-methyl-6-[2-methyl-5-(4H-[1,2,4]triazol-3-yl)-phenyl]-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one: MS (M+H)=418, MP=214.9-216.0° C.

Sources & evidence

ORD record
ord-5f2bf492190c4e87832f64099cfd578c
Source dataset
uspto-grants-2010_01
Patent number
US07645764B2

Reaction notes

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