Hydrochloric Acid → HCID 58683724, compound

HRID 1991065Notes

Reaction equation

HRID 1991065 reaction equation
C[O:2][C:3](=[O:19])/[CH:4]=[CH:5]/[C:6]1[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][CH:12]=[N:13]2)=[CH:8][C:7]=1[N+:16]([O-:18])=[O:17].[OH-].[Na+].CO.Cl>O>[N+:16]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:6]=1/[CH:5]=[CH:4]/[C:3]([OH:19])=[O:2])[N:13]=[CH:12][CH:11]=[CH:10]2)([O-:18])=[O:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 58683750HCID 58683750, compound

Product 1

HCID 58683724HCID 58683724, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

(E)-3-(6-Nitroquinolin-7-yl)-acrylic acid methyl ester (1 g; 3.9 mmol) was suspended in 2N NaOH (2.9 ml; 5.8 mmol) and MeOH (39 ml) and stirred at 55° C. for 1 h. The clear solution was cooled, treated with 2N HCl (3.2 ml; 6.4 mmol), diluted with water (70 ml) and the precipitated title compound filtered and dried (900 mg; 94%).

Workup

  1. temperatureThe clear solution was cooled
  2. customthe precipitated title compound
  3. filtrationfiltered
  4. customdried (900 mg; 94%)

Sources & evidence

ORD record
ord-f713e4f5b65245169c60498a0dafcdc5
Source dataset
uspto-grants-2010_01
Patent number
US07645760B2

Reaction notes

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