Hydrochloric Acid → HCID 10070556, compound

Participants

Reaction Steps

1.56 g (3.6 mmol) 5-Chloro-2-{(E)-3-[4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-3-oxo-propenyl}-benzoic acid methyl ester (Example 78) was suspended in a 1:1 mixture of methanol and water (20 ml). 0.5 ml 10 N NaOH was added and the mixture was stirred overnight. After acidification using 6.5 ml 1N HCl the product precipitated. Filtration and drying yielded 1.32 g (3.2 mmol, 87%) of the desired acid.

Provenance & Evidence