Hydrochloric Acid → HCID 10070556, compound

HRID 1991086Notes

Reaction equation

HRID 1991086 reaction equation
C[O:2][C:3](=[O:30])[C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:5]=1/[CH:11]=[CH:12]/[C:13]([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH2:17][CH:16]1[CH3:29])=[O:14].CO.[OH-].[Na+].Cl>O>[Cl:10][C:8]1[CH:7]=[CH:6][C:5](/[CH:11]=[CH:12]/[C:13]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][C:22]3[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=3)[CH2:17][CH:16]2[CH3:29])=[O:14])=[C:4]([CH:9]=1)[C:3]([OH:30])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 10410466HCID 10410466, compound

Product 1

HCID 10070556HCID 10070556, compoundYield 88.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.56 g (3.6 mmol) 5-Chloro-2-{(E)-3-[4-(4-fluoro-benzyl)-2-methyl-piperazin-1-yl]-3-oxo-propenyl}-benzoic acid methyl ester (Example 78) was suspended in a 1:1 mixture of methanol and water (20 ml). 0.5 ml 10 N NaOH was added and the mixture was stirred overnight. After acidification using 6.5 ml 1N HCl the product precipitated. Filtration and drying yielded 1.32 g (3.2 mmol, 87%) of the desired acid.

Workup

  1. customprecipitated
  2. filtrationFiltration
  3. customdrying

Sources & evidence

ORD record
ord-faa475b59ae3432d95edd13ad9978d77
Source dataset
uspto-grants-2010_01
Patent number
US07645760B2

Reaction notes

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