HCID 11312262, compound → HCID 11242358, compound

HRID 1991197Notes

Reaction equation

HRID 1991197 reaction equation
CN(C)S(C1C2N(CC(O)=O)C=NC=2C=CC=1)(=O)=O.[N+:20]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([S:29]([CH2:32][CH2:33][CH3:34])(=[O:31])=[O:30])[C:24]=1[NH:35][CH2:36][CH2:37][OH:38])([O-])=O>>[NH2:20][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([S:29]([CH2:32][CH2:33][CH3:34])(=[O:30])=[O:31])[C:24]=1[NH:35][CH2:36][CH2:37][OH:38]

Participants

3

Reactant 2

HCID 11312262HCID 11312262, compoundHCID 11380547HCID 11380547, compound

Product 1

HCID 11242358HCID 11242358, compoundYield 52%

Procedure

The compound was synthesized in 52% yield according to the procedure described for the synthesis of (7-dimethylsulfamoyl-benzimidazol-1-yl)-acetic acid, part C, starting from 2-{[2-nitro-6-(propylsulfonyl)phenyl]amino}ethanol. MS (ESI) m/z 259 [M+H]. 1H NMR (400 MHz, CDCl3/CD3OD) δ ppm 1.00 (t, J=7.3 Hz, 3H), 1.82-1.72 (m, 2H), 3.15-3.11 (m, 2H), 3.29-3.27 (m, 2H), 3.80-3.77 (m, 2H), 6.92-6.90 (m, 1H), 6.96 (t, J=7.8 Hz, 1H), 7.23 (dd, J=7.7, 1.6 Hz, 1H)

Workup

  1. customThe compound was synthesized in 52% yield

Sources & evidence

ORD record
ord-f6262a143caa45ae8e109d97b0b47089
Source dataset
uspto-grants-2010_01
Patent number
US07645784B2

Reaction notes

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