HCID 15219197, compound → 2-amino-3-fluorophenol

HRID 1991333Notes

Reaction equation

HRID 1991333 reaction equation
C([O:8][C:9]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:10]=1[NH2:11])C1C=CC=CC=1>[Pd].CO>[NH2:11][C:10]1[C:12]([F:16])=[CH:13][CH:14]=[CH:15][C:9]=1[OH:8]

Participants

4

Reactant 1

HCID 15219197HCID 15219197, compound

Product 1

HCID 27827782-amino-3-fluorophenolYield 99.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-(Benzyloxy)-6-fluoroaniline (Step 2, 5.00 g, 0.0230 mol) and 10% palladium on carbon (0.5 g) in methanol (100 ml) are stirred under a hydrogen atmosphere (balloon) for 2 h. The catalyst is removed by filtration through a pad of celite and the filtrate concentrated to give pure product as a tan solid (2.9 g, 99%); mp 125-6° C.

Workup

  1. customThe catalyst is removed by filtration through a pad of celite
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-48f67b5a71e24edda6c7adbfed770270
Source dataset
uspto-grants-2010_01
Patent number
US07645781B2

Reaction notes

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