HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 15219197, compound → 2-amino-3-fluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 15219197 | HCID 15219197 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-amino-3-fluorophenol | HCID 2782778 | 99.2% |
Reaction Steps
2-(Benzyloxy)-6-fluoroaniline (Step 2, 5.00 g, 0.0230 mol) and 10% palladium on carbon (0.5 g) in methanol (100 ml) are stirred under a hydrogen atmosphere (balloon) for 2 h. The catalyst is removed by filtration through a pad of celite and the filtrate concentrated to give pure product as a tan solid (2.9 g, 99%); mp 125-6° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645781B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-48f67b5a71e24edda6c7adbfed770270 |
| Source note | uspto-grants-2010_01 |