Ammonium Chloride → 6-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one

HRID 1991342Notes

Reaction equation

HRID 1991342 reaction equation
[CH2:1]([N:3]1[C:7]2[C:8]([F:15])=[CH:9][C:10]([N+:12]([O-])=O)=[CH:11][C:6]=2[O:5][C:4]1=[O:16])[CH3:2].[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:12][C:10]1[CH:9]=[C:8]([F:15])[C:7]2[N:3]([CH2:1][CH3:2])[C:4](=[O:16])[O:5][C:6]=2[CH:11]=1

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 45095618HCID 45095618, compound

Product 1

HCID 684905716-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Prepared from 3-ethyl-4-fluoro-6-nitro-1,3-benzoxazol-2(3H)-one (Step 1, 1.05 g, 4.90 mmol), ammonium chloride (2.62 g, 49 mmol) and iron powder (1.09 g, 19.6 mmol) in ethanol (30 ml) and water (15 ml) according to the method of EXAMPLE 86, Step 7 (0.95 g, 99%).

Sources & evidence

ORD record
ord-435648196410484ca85b0fc1a3a35735
Source dataset
uspto-grants-2010_01
Patent number
US07645781B2

Reaction notes

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