3-Formylphenylboronic acid → HCID 59128923, compound

HRID 1991383Notes

Reaction equation

HRID 1991383 reaction equation
Br[C:2]1[S:6][C:5]([NH:7][C:8]2[C:9]([O:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:21]([CH3:24])([CH3:23])[CH3:22])=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:4][C:3]=1[C:25]([F:28])([F:27])[F:26].[CH:29]([C:31]1[CH:32]=[C:33](B(O)O)[CH:34]=[CH:35][CH:36]=1)=[O:30]>>[C:21]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[O:14][C:9]1[C:8]([NH:7][C:5]2[S:6][C:2]([C:35]3[CH:36]=[C:31]([CH:32]=[CH:33][CH:34]=3)[CH:29]=[O:30])=[C:3]([C:25]([F:28])([F:27])[F:26])[N:4]=2)=[CH:13][CH:12]=[CH:11][N:10]=1)([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 27343563-Formylphenylboronic acidHCID 59128919HCID 59128919, compound

Product 1

HCID 59128923HCID 59128923, compound

Procedure

Example 374a was synthesized from N-(5-bromo-4-(trifluoromethyl)thiazol-2-yl)-2-(2-tert-butylphenoxy)pyridin-3-amine (Example 323a) and 3-formylphenyl boronic acid according to a similar procedure described for Example 107. Example 374a was obtained as a white foam. (M+H)+=498.3.

Workup

  1. customExample 374a was obtained as a white foam

Sources & evidence

ORD record
ord-497b75e3d5784b3e84253355a4f2a73a
Source dataset
uspto-grants-2010_01
Patent number
US07645778B2

Reaction notes

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