Morpholine → HCID 68688558, compound

HRID 1991403Notes

Reaction equation

HRID 1991403 reaction equation
[O:1]([CH2:8][C:9]([N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C@@H:12]1[C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[CH:24][CH:23]=2)[N:18]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C.[NH:62]1[CH2:67][CH2:66][O:65][CH2:64][CH2:63]1>CN(C=O)C>[N:62]1([C:26]([C:25]2[CH:24]=[CH:23][C:22]([C:19]3[N:18]=[C:17]([C@H:12]4[CH2:13][CH2:14][CH2:15][CH2:16][N:11]4[C:9](=[O:10])[CH2:8][O:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[O:21][N:20]=3)=[CH:30][CH:29]=2)=[O:27])[CH2:67][CH2:66][O:65][CH2:64][CH2:63]1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 68687354HCID 68687354, compoundHCID 86612874HCID 86612874, compound

Product 1

HCID 68688558HCID 68688558, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.07 mmol of (R)-4-{5-[1-(2-Phenoxy-acetyl)-piperidin-2-yl]-[1,2,4]oxadiazol-3-yl}-benzoic acid were treated with 1 eq. of TBTU/DIPEA in 1 ml DMF for 10 min and 2 eq. of Morpholine added. Ther reaction is stirred overnight at room temperature and the product isolated via preperative HPLC.

Workup

  1. customthe product isolated via preperative HPLC

Sources & evidence

ORD record
ord-335403260f9d445ebdef79ee5917f336
Source dataset
uspto-grants-2010_01
Patent number
US07645776B2

Reaction notes

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