反应详情

34 mg of (R)-4-{5-[1-(2-Phenoxy-acetyl)-piperidin-2-yl]-[1,2,4]oxadiazol-3-yl}-benzoic acid were treated with 1 eq HATU/DIPEA in DMF and added to 1 eq of Rink-Resin. The reaction was shaken overnight at room temperature. The resin was washed with DMF, MeOH, DCM (3 times each) and then treated with TFA/DCM (1:1) for 2 h. The resulting yellow oil was purified via preparative HPLC.

1. washThe resin was washed with DMF, MeOH, DCM (3 times each) and
2. additionthen treated with TFA/DCM (1:1) for 2 h
3. customThe resulting yellow oil was purified via preparative HPLC