Sodium Carbonate → N-hydroxy-4-sulfamoylbenzene-1-carboximidamide

HRID 1991412Notes

Reaction equation

HRID 1991412 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH2:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].Cl.[NH2:14][OH:15].C([O-])([O-])=O.[Na+].[Na+]>C(O)C.O>[OH:15][NH:14][C:1](=[NH:2])[C:3]1[CH:8]=[CH:7][C:6]([S:9](=[O:11])(=[O:10])[NH2:12])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 76566p-CyanobenzenesulphonamideHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 612025N-hydroxy-4-sulfamoylbenzene-1-carboximidamide

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Conditions

Temperature
80 °C

Procedure

1 mmol of 4-Cyano-benzenesulfonamide are dissolved in a mixture of ethanol/water (7:3) and 5 eq of hydroxylamine hydrochloride and 2.5 eq. Na2CO3 added. The suspension is heated to 80° C. for 2 h. After evaporation of the solvent mixture the resulting material is extracted from ethylacetate/water. The product was not further characterized.

Workup

  1. customAfter evaporation of the solvent mixture the resulting material
  2. extractionis extracted from ethylacetate/water

Sources & evidence

ORD record
ord-f6fbdd762d8a4613ab95f72d8abfe7d2
Source dataset
uspto-grants-2010_01
Patent number
US07645776B2

Reaction notes

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