Lithium Hydroxide → HCID 59129736, compound

HRID 1991453Notes

Reaction equation

HRID 1991453 reaction equation
C([O:4][C:5]1[C:6]([CH3:23])=[C:7]2[C:14]([NH2:15])=[C:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[S:12][C:8]2=[N:9][C:10]=1[CH3:11])(=O)C.[Li+].[OH-]>CO>[NH2:15][C:14]1[C:7]2[C:8](=[N:9][C:10]([CH3:11])=[C:5]([OH:4])[C:6]=2[CH3:23])[S:12][C:13]=1[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 59129738HCID 59129738, compound

Product 1

HCID 59129736HCID 59129736, compoundYield 702.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl 5-acetoxy-3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylate (19.6 g, 5.8 mmol) in methanol (300 mL), was added a 5% solution of aqueous LiOH (150 mL) and the mixture was stirred overnight. The precipitate was collected and washed with water to provide tert-butyl 3-amino-5-hydroxy-4,6-dimethyl-thieno [2,3-b]pyridine-2-carboxylate (12 g, 71%).

Workup

  1. customThe precipitate was collected
  2. washwashed with water

Sources & evidence

ORD record
ord-5f492a81bae34d818f93ce49b9ec6708
Source dataset
uspto-grants-2010_01
Patent number
US07645881B2

Reaction notes

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