HCID 13097133, compound → HCID 13097132, compound

HRID 1991474Notes

Reaction equation

HRID 1991474 reaction equation
C([O:3][C:4](=[O:17])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([Cl:15])=[CH:12][CH:13]=2)[CH2:8][C:7]1=[O:16])C>Cl>[Cl:15][C:11]1[CH:10]=[C:9]2[C:14](=[CH:13][CH:12]=1)[N:6]([CH2:5][C:4]([OH:17])=[O:3])[C:7](=[O:16])[CH2:8]2

Participants

3

Reactant 1

HCID 13097133HCID 13097133, compound

Product 1

HCID 13097132HCID 13097132, compoundYield 84.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
80 °C

Procedure

In a two neck flask, ethyl (5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)acetate 58 (0.1 g, 0.39 mmol) was stirred overnight at room temperature in aqueous HCl (6 M, 2 ml) and warmed at 80° C. until disappearance of the starting material by TLC. The reaction mixture was cooled down to room temperature, filtered and the filtrate was washed by cold water to afford (5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)acetic acid 59 (74 mg).

Workup

  1. temperatureThe reaction mixture was cooled down to room temperature
  2. filtrationfiltered
  3. washthe filtrate was washed by cold water

Sources & evidence

ORD record
ord-4591187ec91145609d27d08a4c75fd30
Source dataset
uspto-grants-2010_01
Patent number
US07645887B2

Reaction notes

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