Hydrochloric Acid → HCID 68689708, compound

HRID 1991477Notes

Reaction equation

[ClH:1].C(OC(=O)[NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]([C:32](=O)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[CH:16]([CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[C:17](=[O:25])[NH:18][CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)(C)(C)C>CO>[ClH:1].[CH:26]1([CH:16]([N:15]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[N:8]=[C:32]2[C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:17]([NH:18][CH:19]2[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]2)=[O:25])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]1

Participants

Conditions

Temperature: 145 °C

Procedure

Concentrated HCl (25% in water, 0.5 mL) was added to a solution of {2-[benzoyl-(cyclohexyl-cyclohexylcarbamoyl-methyl)-amino]phenyl}-carbamic acid tert-butyl ester (64 mg, 0.12 mmol) in methanol (2.0 mL). The reaction mixture was heated in a focussed microwave (CEM Discovery) at 145° C., for 3 minutes with stirring. The reaction mixture was then evaporated to afford 2,N-dicyclohexyl-2-(2-phenyl-benzoimidazol-1-yl)-acetamide hydrogen chloride, 46 mg (85%) as a pale yellow solid. MS (ES+): 416 (M+H).

Workup

customThe reaction mixture was then evaporated

Sources & evidence

ORD record: ord-4ee67b2081b647ba99998746ff8f6c32
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07645785B2

Reaction notes

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