反应详情

To dibromobenzylamine (1S,2R) N-[3-(2,5-Dibromo-benzylamino)-1-(3,5-difluoro-benzyl)-2-hydroxy-propyl]-acetamide (0.504 g, 1.0 mM, 1 eq) was added 0.5 M THF solution of neopentylzinc iodide (20 mL, 10 eq) and 0.082 g, (0.1 mM, 0.1 eq) of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (Pd(dppf)Cl2 CH2Cl2). A reaction mixture was stirred overnight at room temperature. The reaction was quenched with a saturated aqueous solution of NH4Cl (20 mL) and extracted with ethyl acetate (3×30 mL). Combined organic layers were washed with brine, dried and concentrated.

1. customThe reaction was quenched with a saturated aqueous solution of NH4Cl (20 mL)
2. extractionextracted with ethyl acetate (3×30 mL)
3. washCombined organic layers were washed with brine
4. customdried
5. concentrationconcentrated