Thionyl Chloride → HCID 23134842, compound

HRID 1991918Notes

Reaction equation

HRID 1991918 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[C:23]([F:26])[C:24]=1[F:25])[O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=1.S(Cl)([Cl:29])=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[C:23]([F:26])[C:24]=1[F:25])[O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([Cl:29])=[O:18])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 23134841HCID 23134841, compound

Product 1

HCID 23134842HCID 23134842, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
35 °C

Procedure

About 10 g (about 27.148 mmol) of 4-[6-(3,4,5-Trifluoro-phenoxy)-hexyloxy]-benzoic acid was dissolved in about 200 ml of methylene chloride, and then added with about 3.55 g (about 29.862 mmol) of thionyl chloride. The reaction mixture was stirred at about 35° C. for about 6 hours, and the solvent was removed. Through a vacuum drying process, the desired compound was obtained (Yield about 95%).

Workup

  1. customthe solvent was removed
  2. customThrough a vacuum drying process

Sources & evidence

ORD record
ord-34bc26401e06496780bfefbbd42bd56e
Source dataset
uspto-grants-2010_01
Patent number
US07646014B2

Reaction notes

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