HCID 59128565, compound → HCID 68439019, compound

HRID 1992003Notes

Reaction equation

HRID 1992003 reaction equation
[CH3:1][O:2][N:3]1[CH2:8][CH:7]=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:5][CH2:4]1>CO.[Pd]>[CH3:1][O:2][N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:10]=[CH:11][C:12]([NH2:15])=[CH:13][CH:14]=2)[CH2:5][CH2:4]1

Participants

4

Reactant 1

HCID 59128565HCID 59128565, compound

Product 1

HCID 68439019HCID 68439019, compoundYield 92.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 4-(1-methoxy-1,2,3,6-tetrahydro-pyridin-4-yl)-phenylamine (as prepared in previous step) (40.8 mg, 0.200 mmol) in MeOH (5 mL) was hydrogenated over 10% Pd/C (20.4 mg) at 20 psi for 1 h. The solution was filtered through a pad of Celite and concentrated to give 4-(1-methoxy-piperidin-4-yl)-phenylamine (38 mg, 92%) which was directly used in the next step without purification.

Workup

  1. filtrationThe solution was filtered through a pad of Celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-f917d58cf5b94d7abf5cc7f13ea66666
Source dataset
uspto-grants-2010_01
Patent number
US07645755B2

Reaction notes

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