HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59128565, compound → HCID 68439019, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59128565 | HCID 59128565 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68439019 | HCID 68439019 | 92.1% |
Reaction Steps
A solution of 4-(1-methoxy-1,2,3,6-tetrahydro-pyridin-4-yl)-phenylamine (as prepared in previous step) (40.8 mg, 0.200 mmol) in MeOH (5 mL) was hydrogenated over 10% Pd/C (20.4 mg) at 20 psi for 1 h. The solution was filtered through a pad of Celite and concentrated to give 4-(1-methoxy-piperidin-4-yl)-phenylamine (38 mg, 92%) which was directly used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07645755B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-f917d58cf5b94d7abf5cc7f13ea66666 |
| Source note | uspto-grants-2010_01 |