Ammonium Hydroxide → HCID 58727710, compound

HRID 1992074Notes

Reaction equation

HRID 1992074 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-].[NH4+:16]>>[NH2:16][S:11]([C:8]1[CH:9]=[N:10][C:2]([Cl:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5])(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 574159692-Chloro-5-(chlorosulfonyl)pyridine-3-carboxylic acid

Product 1

HCID 58727710HCID 58727710, compound

Procedure

2-Chloro-5-(chlorosulfonyl)nicotinic acid (400 mg, 1.56 mmol) was stirred in a slurry of ice and excess ammonium hydroxide was added at 0° C. and stirred until all of the ice had melted. The resulting solution was evaporated to afford a white solid 5-(aminosulfonyl)-2-chloronicotinic acid. MS ES+ 237 (M+H). 1H NMR (400 MHz, DMSO-D6) δ ppm 8.1 (dd, J=2.6, 0.9 Hz, 1H), 8.6 (m, 1H).

Workup

  1. additionwas added at 0° C.
  2. customThe resulting solution was evaporated

Sources & evidence

ORD record
ord-2cd57edea40a4b3f8c73a22d642c3ec2
Source dataset
uspto-grants-2010_01
Patent number
US07645771B2

Reaction notes

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