Hydrogen Bromide → HCID 68677541, compound

HRID 1992114Notes

Reaction equation

HRID 1992114 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:22][CH2:23][N:24]3[CH:29]4[CH2:30][CH2:31][CH:25]3[CH2:26][CH:27]([N:32]3[C:36]5[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=5[N:34]=[C:33]3[CH3:41])[CH2:28]4)[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[BrH:42]>>[BrH:42].[CH3:41][C:33]1[N:32]([CH:27]2[CH2:28][CH:29]3[N:24]([CH2:23][CH2:22][C:9]4([C:5]5[CH:4]=[C:3]([OH:2])[CH:8]=[CH:7][CH:6]=5)[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]4)[CH:25]([CH2:31][CH2:30]3)[CH2:26]2)[C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=2[N:34]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 68677250HCID 68677250, compound

Product 1

HCID 68677541HCID 68677541, compound

Conditions

Temperature
100 °C

Procedure

A mixture of tert-butyl 4-(3-methoxy phenyl)-4-{2-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]ethyl}piperidine-1-carboxylate (235 mg, 0.42 mmol) and 48% hydrobromic acid was heated at 100° C. for 6 h. The mixture was concentrated and used without further purification.

Workup

  1. concentrationThe mixture was concentrated
  2. customused without further purification

Sources & evidence

ORD record
ord-3b25f7bc74244a6ab59c7298320bac2e
Source dataset
uspto-grants-2010_01
Patent number
US07645771B2

Reaction notes

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