Hydrochloric Acid → HCID 68541705, compound

Participants

Reaction Steps

To a solution of (S)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine (160 mg, 0.531 mmoles) in THF (4 mL) is added a saturated solution of HCl in dioxane (2 mL) at 0° C. The reaction mixture is allowed to stir at room temperature for 4 h. The solvent is removed under reduced pressure. The resulting solid is washed repeatedly with anhydrous ether and dried under reduced pressure to give title compound (87% yield): MS (m/z): 302 (M+1).

Provenance & Evidence