Hydrochloric Acid → HCID 68541705, compound

HRID 1992296Notes

Reaction equation

HRID 1992296 reaction equation
[F:1][C:2]1[C:7]([C:8]2[CH:9]=[C:10]([C@:14]3([CH3:21])[CH2:19][CH2:18][S:17][C:16]([NH2:20])=[N:15]3)[CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:22]>C1COCC1.O1CCOCC1>[ClH:22].[ClH:22].[F:1][C:2]1[C:7]([C:8]2[CH:9]=[C:10]([C@:14]3([CH3:21])[CH2:19][CH2:18][S:17][C:16]([NH2:20])=[N:15]3)[CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57948953HCID 57948953, compound

Product 1

HCID 68541705HCID 68541705, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (S)-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine (160 mg, 0.531 mmoles) in THF (4 mL) is added a saturated solution of HCl in dioxane (2 mL) at 0° C. The reaction mixture is allowed to stir at room temperature for 4 h. The solvent is removed under reduced pressure. The resulting solid is washed repeatedly with anhydrous ether and dried under reduced pressure to give title compound (87% yield): MS (m/z): 302 (M+1).

Workup

  1. customThe solvent is removed under reduced pressure
  2. washThe resulting solid is washed repeatedly with anhydrous ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-0a6c4cb8147a4b53aa12f8d02ed8462c
Source dataset
uspto-grants-2010_01
Patent number
US07648983B2

Reaction notes

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