Phosphorus oxychloride → HCID 59130280, compound

HRID 1992305Notes

Reaction equation

HRID 1992305 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][C:2]=1[C:11]1[N:12]=[C:13](O)[C:14]2[S:19][CH:18]=[CH:17][C:15]=2[N:16]=1.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:13]1[C:14]2[S:19][CH:18]=[CH:17][C:15]=2[N:16]=[C:11]([C:2]2[CH:3]=[N:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)[N:12]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178517553HCID 178517553, compound

Product 1

HCID 59130280HCID 59130280, compound

Procedure

A solution of 2-(2-quinoxalinyl)thieno[3,2-d]pyrimidin-4-ol (150 mg, 0.54 mmol) in POCl3 (5 mL) was heated to reflux and maintained at reflux overnight. After cooling to rt, excess POCl3 was removed under reduced pressure to give the crude product which was used in the next step without further purification.

Workup

  1. temperatureto reflux
  2. temperaturemaintained
  3. temperatureat reflux overnight
  4. customexcess POCl3 was removed under reduced pressure

Sources & evidence

ORD record
ord-a741cf7bdd3f4c94a8b48bf8e44afc64
Source dataset
uspto-grants-2010_01
Patent number
US07648986B2

Reaction notes

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