反应详情

1-(2,2,2-Trifluoroacetyl)-2,3-dihydro-1H-indole-5-carbonitrile (13 g, 0.0542 mol; see step (iii) above) was dissolved in THF (100 mL), to which 1% NaOH was then added. After stirring for 5 h at RT, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate and solvent was evaporated to provide the sub-title compound as a pale yellow solid. Yield: 8 g.

1. additionwas then added
2. extractionthe reaction mixture was extracted with ethyl acetate
3. washThe organic layer was washed with water and brine
4. dry with materialdried over sodium sulfate and solvent
5. customwas evaporated