Hydrochloric Acid → HCID 131727848, compound

HRID 1992342Notes

Reaction equation

HRID 1992342 reaction equation
[O:1]=[C:2]([N:21]1[C:29]2[C:24](=[CH:25][C:26]([C:30]#[N:31])=[CH:27][CH:28]=2)[CH2:23][CH2:22]1)[CH2:3][CH2:4][N:5]1[CH2:12][CH:11]2[O:13][CH:7]([CH2:8][N:9](C(OC(C)(C)C)=O)[CH2:10]2)[CH2:6]1.[ClH:32]>O1CCOCC1>[ClH:32].[CH:11]12[O:13][CH:7]([CH2:8][NH:9][CH2:10]1)[CH2:6][N:5]([CH2:4][CH2:3][C:2]([N:21]1[C:29]3[C:24](=[CH:25][C:26]([C:30]#[N:31])=[CH:27][CH:28]=3)[CH2:23][CH2:22]1)=[O:1])[CH2:12]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86625992HCID 86625992, compound

Product 1

HCID 131727848HCID 131727848, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 7-[3-oxo-3-(5-cyano-2,3-dihydro-1H-indol-1-yl)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (5 g, 0.017 mol; see step (vi) above) was taken up in 50 mL of dioxane that was saturated with HCl gas. The mixture was then stirred for 1 h under nitrogen atmosphere at RT. The resulting solid was filtered and washed with ether and then dried under vacuum to yield 4.42 g of the title compound as an off white solid.

Workup

  1. filtrationThe resulting solid was filtered
  2. washwashed with ether
  3. customdried under vacuum

Sources & evidence

ORD record
ord-028cfec57a464bec8c147670e8e1bbb3
Source dataset
uspto-grants-2010_01
Patent number
US07648985B2

Reaction notes

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