反应详情

4-Cyanobenzenesulfonyl chloride (6 g, 0.0297 mol) in 50 ml of dry DCM was added at 0° C. to a solution of N-methylethanolamine (2.67 g, 0.0356 mol) and triethylamine (7.49 g, 0.0742 mol) in dry dichloromethane (75 ml) under nitrogen atmosphere and stirred at RT for 2 h. The reaction mixture was quenched with water and extracted with dichloromethane. Organic layer was washed with water and brine and dried over sodium sulfate. Solvent evaporation under reduced pressure afforded crude product as solid. This solid was then washed with petroleum ether (three times) and dried under vacuum to give the sub-title compound (5.18 g) as white solid.

1. customThe reaction mixture was quenched with water
2. extractionextracted with dichloromethane
3. washOrganic layer was washed with water and brine
4. dry with materialdried over sodium sulfate
5. customSolvent evaporation under reduced pressure
6. customafforded crude product as solid
7. washThis solid was then washed with petroleum ether (three times)
8. customdried under vacuum