Trifluoroacetic acid → HCID 131727851, compound

Participants

Reaction Conditions

Reaction Steps

(3-{7-[2-(4-Cyano-2-fluoro-phenoxy)-ethyl]-9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl}-propyl)-carbamic acid isopropyl ester (5.8 g, from step (ii) above) was taken in dry dichloromethane (25 ml) and cooled to 0° C. Trifluoroacetic acid (75 ml) was added drop by drop and the reaction mixture was stirred at RT for 2 h under nitrogen atmosphere. Solvent and trifluoroacetic acid were evaporated under reduced pressure to give the TFA salt of the sub-title compound (9 g) as an oil.

Provenance & Evidence