Trifluoroacetic acid → HCID 131727851, compound

HRID 1992369Notes

Reaction equation

C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:18][CH:17]2[O:19][CH:13]([CH2:14][N:15]([CH2:20][CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][C:24]=3[F:31])[CH2:16]2)[CH2:12]1)(C)(C)C.[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36]>ClCCl>[OH:37][C:35]([C:34]([F:39])([F:38])[F:33])=[O:36].[NH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:18][CH:17]2[O:19][CH:13]([CH2:14][N:15]([CH2:20][CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][C:24]=3[F:31])[CH2:16]2)[CH2:12]1

Participants

Conditions

Temperature: 0 °C

Procedure

(3-{7-[2-(4-Cyano-2-fluoro-phenoxy)-ethyl]-9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl}-propyl)-carbamic acid isopropyl ester (5.8 g, from step (ii) above) was taken in dry dichloromethane (25 ml) and cooled to 0° C. Trifluoroacetic acid (75 ml) was added drop by drop and the reaction mixture was stirred at RT for 2 h under nitrogen atmosphere. Solvent and trifluoroacetic acid were evaporated under reduced pressure to give the TFA salt of the sub-title compound (9 g) as an oil.

Workup

customSolvent and trifluoroacetic acid were evaporated under reduced pressure

Sources & evidence

ORD record: ord-a5ed0ff3fbcf4d378b14b5bb06b623cb
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07648985B2

Reaction notes

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