HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromopropane → 4-(3-Bromopropoxy)-3,5-difluorobenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromopropane | HCID 8001 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,5-Difluoro-4-hydroxy-benzonitrile | HCID 10749406 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(3-Bromopropoxy)-3,5-difluorobenzonitrile | HCID 68520030 | 91.5% |
Reaction Steps
A mixture of 2,6-difluoro-4-cyanophenol (6 g, 0.038 mol), 1,3-dibromopropane (46.9 g, 0.23 mol) and dry potassium carbonate (8 g, 0.058 mol) in dry DMF (50 ml) was stirred at RT overnight under nitrogen atmosphere. Solvent was removed under reduced pressure and the residue was purified by column chromatography over silica gel using 4% ethyl acetate in petroleum ether as eluent to yield (9.6 g) of the title compound as a liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07648985B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-5e9bc65c4a464ee4a0296fb09f408e6f |
| Source note | uspto-grants-2010_01 |