反应详情

A mixture of 2,6-difluoro-4-cyanophenol (6 g, 0.038 mol), 1,3-dibromopropane (46.9 g, 0.23 mol) and dry potassium carbonate (8 g, 0.058 mol) in dry DMF (50 ml) was stirred at RT overnight under nitrogen atmosphere. Solvent was removed under reduced pressure and the residue was purified by column chromatography over silica gel using 4% ethyl acetate in petroleum ether as eluent to yield (9.6 g) of the title compound as a liquid.

1. customSolvent was removed under reduced pressure
2. customthe residue was purified by column chromatography over silica gel using 4% ethyl acetate in petroleum ether as eluent