反应详情

温度

60 °C

A mixture of 4-cyano-2-fluoro phenol (5 g, 0.0365 mol; from prep N(iv) above), 3-bromopropanol (10.15 g, 0.073 mol) and potassium carbonate (7.6 g, 0.054 mol) in dry acetone (50 ml) was stirred at 60° C. overnight under nitrogen atmosphere. The reaction mixture was filtered and the solvent was concentrated under reduced pressure. The residue was purified by column chromatography over silica gel using 5% ethyl acetate in petroleum ether to yield (5.5 g) of the sub-title compound as a solid.

1. filtrationThe reaction mixture was filtered
2. concentrationthe solvent was concentrated under reduced pressure
3. customThe residue was purified by column chromatography over silica gel using 5% ethyl acetate in petroleum ether